The Combination of Epigallocatechin Gallate and Lactiplantibacillus plantarum P101 Alleviated Carbon Tetrachloride-Induced Liver Injury in Mice by Regulating Gut Microbiota

Epigallocatechin gallate (EGCG) is a main active ingredient in tea, but it difficult for to be absorbed and utilized by the body, resulting limited bioactivity. Therefore, we explored role of probiotics enhancing physiological activity EGCG mice model liver injury. Mice were methodically treated with either single or combination Lactiplantibacillus plantarum P101 (LP.P101) 21 days, then administrated intraperitoneal injection carbon tetrachloride (CCl4) on last day. As result, antioxidative genes activated pro-inflammatory suppressed, reducing oxidative inflammatory injury mice, which indicated better preventive effect LP.P101 than ingredient. Furthermore, 16S rRNA high-throughput sequencing revealed gut microbiota played mitigation. The increased relative abundance Lactobacillus, Akkermansia other beneficial bacteria that negatively correlated inflammation positively antioxidation. In conclusion, was more effective alleviating damage caused CCl4. Altered may an important cause.